Arginine is a basic amino acid with a positive charge at neutral pH. Its symbol is R in one-letter code and Arg in three-letter code.
In 1886 the Swiss chemist Ernst Schulze isolated it for the first time from Lupine seed extract.
It is an essential amino acids in adult humans. In the liver tissue, it can be synthesized in the ornithine cycle or urea cycle. This amino acid is involved in many activities of the endocrine glands. It is involved in the preservation of the balance of nitrogen and carbon dioxide.
It also has a great importance in the production of hormone growth, directly involved in the growth of tissues and muscles, and in the maintenance and repair of the immune system and nervous system. It can stimulate immune function by increasing the number of leukocytes.
Arginine is involved in the synthesis of creatine, polyamides and in RNA.
On the other hand, L-arginine is the metabolic precursor of nitric oxide or nitrogen oxide, which is a Messenger substance that stimulates the hair growth with the opening of potassium channels, known as K-canales. Although it is not proven scientifically, yes it has been shown to indirectly help other substances to prevent and combat hair loss.
In the body, the synthesis of arginine occurs mainly via the intestinal-renal axis, where the lining of the small intestine, which produce citrulline primarily from glutamine and glutamate, collaborate with the proximal tubular cells of the pancreas, which extract citrulline from the circulation and converts it to arginine, which is placed in circulation.
As a result, intestinal or kidney function abnormalities can reduce endogenous arginine synthesis, making it necessary to raise the amino acid requirement in the diet.
These are some of its most important functions performed in the body:
• Actively participates in the growth since it stimulates your hormone (somatotropin).
• Aids in the production of muscle energy.
• Enhances the activity of the thymus gland and T lymphocytes.
• It can stimulate immune function by increasing the number of leukocytes.
• May play a role in the prevention and treatment of cancer.
• Protects and detoxifies the liver.
• Enhances the synthesis of collagen thereby accelerating the healing of wounds.
• Improves the quantity and motility of sperm.
• Help in cases of impotence.
• Helps reduce cholesterol and therefore reduce the risk of arteriosclerosis.
• Help in female infertility.
• Have therapeutic utility in interstitial cystitis because it prevents the bladder suffers from the strong contractions that cause pain.
• Alleviates diseases caused by continuous and strong muscle contractions as it has the ability to cause nitric oxide production, which is a chemical that relaxes spasms.
• Proven therapeutic effectiveness as a nutrient in the treatment of hemorrhoids even though many believe it may be caused by spasms of the anal sphincter level.
• Through clinical experience, it has been proven that you can use this substance as a preventive agent of heart attacks because it dilates the arteries, thus avoiding the formation of blood clots and also prevents the production of plates in the arterial vascular walls.
• Can be used in the treatment of Peyronie’s disease to dissolve the scar tissue of the penis that characterizes this disease.
• The same goes for the heart valve damage associated with fenfluramine. It has been successfully used as nutritional support in the systemic inflammatory response syndrome and multiple organ failure in trauma patients.
• Preventing and combating the loss of hair.
• Is involved in the synthesis of creatine, polyamines and DNA.
• Helps reduce body fat.
Its deficiency can cause:
Its deficiency can cause a number of disorders in the body, these are some of them:
• Alterations in the growth.
• Weakness and muscle fatigue.
• More likely to have atherosclerosis.
• It causes the excessive presence of ammonia or lysine.
• Hair fall.
• Fatty liver.
All measurements are in micromoles per liter (micro mol / L). Normal values ??vary among different laboratories. Talk to your doctor about the meaning of your specific test results.
Children: From 44-120
Adults: From 13-64
Precautions and Facts to consider:
1. In theory, arginine may increase the risk of bleeding if taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding with the use of ginkgo biloba, and fewer cases with garlic and saw palmetto have been reported. Theoretically, many other agents can increase the risk of bleeding, although in most cases this has not been demonstrated.
2. Arginine may increase blood sugar levels. The person that they use herbs or supplements that may increase blood sugar levels, such as cocoa, dehydroepiandrosterone (DHEA), ephedra (if combined with caffeine), or melatonin should be monitored closely by their health care professional while they are using arginine. It might be necessary to adjust the dosage.
3. Individuals with herpes (either oral herpes [herpes simplex] or genital herpes) should not supplement with arginine, since this amino acid may stimulate virus replication.
4. L-arginine, although it is considered likely safe, can produce some side effects such as abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, respiratory tract inflammation, asthma worsening and low blood pressure.
5. The L-arginine may lower blood pressure as it participates in the formation of nitric oxide.
6. The L-arginine can cause indigestion, nausea and headaches.
7. Taken in high doses can increase the level of acid in the stomach, since it stimulates the production of gastrin, polypeptide hormone which stimulates the secretion of gastric acid by the parietal cells of the stomach. It is therefore possible that can worsen the people who suffer from stomach ulcers and heartburn.
8. L-arginine may alter potassium levels, especially in people with liver disease, patients with kidney problems or those taking ACE inhibitors or diuretics scarce in potassium; they should not take this amino acid.
9. Its consumption may also alter other chemical elements and electrolytes in the body, such as chlorine, sodium, and phosphorus.
10. The pregnant and breast feeding women, should not consume this amino acid as it is not proven to be safe in such cases.
11. This amino acid is destroyed by heat, between 39 ° and 50 ° C.
12. There is concern that it could interfere with the control of blood pressure during and after surgery. Stop taking L-arginine at least 2 weeks before surgery.
13. To enhance the effectiveness of this supplement , should be taken on an empty stomach or after a meal rich in carbohydrates and low in protein to avoid competition with other amino acids.
14. Must take a dose before bedtime to increase its stimulating effects of GH ( growth hormone ) , as this hormone is secreted during sleep at night.
15. Do not take double doses. Taking doses too close can result in stomach discomfort.
The following doses have been studied in scientific research:
• For congestive heart failure: Doses ranging from 6 to 20 grams per day in three divided doses.
• For chest pain associated with coronary artery disease (angina pectoris): Used 3-6 grams three times daily for a period of up to one year.
• To prevent the loss of effect of nitroglycerin that is used to relieve pain in people with chest pain due to coronary artery disease (angina pectoris): Used 700 mg four times a day.
• For organic erectile dysfunction (ED): used 5 grams a day. The lower doses may not be effective.
• To prevent inflammation of the digestive tract in premature infants: are added 261 mg / kg daily to oral feeding for the first 28 days of life.
• For adult men and women, the required dose is 1.5 to 3 g / day.
Foods rich in Arginine:
These are the foods richest in it:
Plant origin: garlic, Chicory, Onion, Coles, Asparagus, Lettuce, Cucumber.
Animal origin: Skim milk powder, Mortadella, Frankfurters sausages, Burgers, Red meat, Veal, beef liver, Cordero, Pollo, fish, Dairy, Seafood, Crustaceans, Fish oil.
Fruits: Peach, Bananas.
Nuts: Almonds, Sprockets, nuts, Cashews, Peanuts, Raisins.
Other: Chocolate, Brewer’s yeast.
Diseases in which its use can be recommended:
These are some of the diseases where the use of this amino acid may be indicated:
• Angina pectoris.
• Cramps muscle.
• Healing of ulcers and wounds.
• Cystitis Interstitial.
• Intermittent claudication: recurrent pain in the legs due to arteries that are blocked.
• Hepatic congestion.
• Cellular degeneration.
• Senile dementia.
• Blood clearance .
• Peyronie’s disease.
• Diseases of the coronary arteries.
• Hepatic steatosis.
• Impotence, infertility male.
• Inflammation of the bladder.
• Congestive heart failure.
• Improved renal function after kidney transplantation in people who are taking
• Prevent digestive tract inflammation in premature infants.
• Syndrome inflammatory response systemically.
• Growth disorders.
• Disorders of the Thyroid.